The presence of thousands of functional long non-coding RNAs (lncRNAs) in the mammalian genome represents a missing component in our understanding of genome regulation.
Our lab aims to understand how lncRNAs control gene expression programs and cell state decisions in the context of mouse embryonic stem cells. We are an integrated team of experimental and computational biologists who work together to address these questions using genomic approaches in conjunction with biochemistry, molecular biology, cell biology, and computational biology.
